Targeted disruption of the ATP2A1 gene encoding the sarco(endo)plasmic reticulum Ca2+ ATPase isoform 1 (SERCA1) impairs diaphragm function and is lethal in neonatal mice
Mutations in the ATP2A1 gene, encoding isoform 1 of the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA1), are one cause of Brody disease, characterized in humans by exercise-induced contraction of fast twitch (type II) skeletal muscle fibers. In an attempt to create a model for Brody disease, the m...
|Journal Title:||Journal of Biological Chemistry Vol. 278; no. 15; pp. 13367 - 13375|
|Authors:||William J. Rice, David H. MacLennan, Yan Pan, Elena Zvaritch, A. R. Tupling, Stella De Leon, Michael Rudnicki, Colin McKerlie, Brenda L. Banwell|
American Society for Biochemistry and Molecular Biology Inc,