Functional consequences of alterations to hydrophobic amino acids located in the M4 transmembrane sector of the Ca2+-ATPase of sarcoplasmic reticulum

Those Hydrophobic residues between Ile298 and Ile315 in transmembrane segment M4 of the Ca2+-ATPase of sarcoplasmic reticulum, not previously mutated, were mutated systematically in ways that would alter their size or polarity, and functional consequences were measured. Fourteen residues in this seq...

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Journal Title: Journal of Biological Chemistry Vol. 268; no. 24; pp. 18359 - 18364
Authors: William J. Rice, David M. Clarke, Tip W. Loo, Jens P. Andersen, Bente Vilsen, David H. MacLennan
Format: Article
Published: American Society for Biochemistry and Molecular Biology Inc, 1993