Spatial and Dynamic Interactions between Phospholamban and the Canine Cardiac Ca2+ Pump Revealed with Use of Heterobifunctional Cross-linking Agents
Heterobifunctional thiol to amine cross-linking agents were used to gain new insights on the dynamics and conformational factors governing the interaction between the cardiac Ca2+ pump (SERCA2a) and phospholamban (PLB). PLB is a small protein inhibitor of SERCA2a that reduces enzyme affinity for Ca2...
|Journal Title:||Journal of Biological Chemistry Vol. 278; no. 48; pp. 48348 - 48356|
|Authors:||Zhenhui Chen, David L. Stokes, William J. Rice, Larry R. Jones|
American Society for Biochemistry and Molecular Biology Inc,