Spatial and Dynamic Interactions between Phospholamban and the Canine Cardiac Ca2+ Pump Revealed with Use of Heterobifunctional Cross-linking Agents

Heterobifunctional thiol to amine cross-linking agents were used to gain new insights on the dynamics and conformational factors governing the interaction between the cardiac Ca2+ pump (SERCA2a) and phospholamban (PLB). PLB is a small protein inhibitor of SERCA2a that reduces enzyme affinity for Ca2...

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Journal Title: Journal of Biological Chemistry Vol. 278; no. 48; pp. 48348 - 48356
Authors: Zhenhui Chen, David L. Stokes, William J. Rice, Larry R. Jones
Format: Article
Published: American Society for Biochemistry and Molecular Biology Inc, 2003
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