Optimal operation of high pressure homogenization for intracellular product recovery
An optimal control methodology for the homogenization of bacterial cells to recover intracellular products is presented. A Fluent computational fluid dynamics (CFD) model is used to quantify the hydrodynamic forces present in the homogenizer, and empirical models are used to relate these forces to e...
|Journal Title:||Bioprocess and Biosystems Engineering Vol. 27; no. 1; pp. 25 - 37|
|Authors:||William J. Kelly, Kenneth Muske|