Optimal operation of high pressure homogenization for intracellular product recovery

An optimal control methodology for the homogenization of bacterial cells to recover intracellular products is presented. A Fluent computational fluid dynamics (CFD) model is used to quantify the hydrodynamic forces present in the homogenizer, and empirical models are used to relate these forces to e...

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Journal Title: Bioprocess and Biosystems Engineering Vol. 27; no. 1; pp. 25 - 37
Authors: William J. Kelly, Kenneth Muske
Format: Article
Published: 2005
Dec 2004
Online Access: Full Text