Kinome-level screening identifies inhibition of polo-like kinase-1 (PLK1) as a target for enhancing non-viral transgene expression

Human cells contain hundreds of kinase enzymes that regulate several cellular processes, which likely include transgene delivery and expression. We identified several kinases that influence gene delivery and/or expression by performing a kinome-level screen in which, we identified small-molecule kin...

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Journal Title: Journal of Controlled Release Vol. 204; pp. 20 - 29
Authors: M. D. Christensen, Jacob Elmer, S. Eaton, L. Gonzalez-Malerva, J. Labaer, K. Rege
Format: Article
Language: English
Published: 04/28/2015