Sequence- and Species-Dependence of Proteasomal Processivity

The proteasome is the degradation machine at the center of the ubiquitin-proteasome system and controls the concentrations of many proteins in eukaryotes. It is highly processive so that substrates are degraded completely into small peptides, avoiding the formation of potentially toxic fragments. No...

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Journal Title: ACS Chemincal Biology Vol. 7; no. 8; pp. 1444 - 1453
Authors: Daniel Kraut, Eitan Israeli, Erin K. Schrader, Ashwini Patil, Kenta Nakai, Dhaval Nanavati, Tomonao Inobe, Andreas Matouschek
Format: Article
Language: English
Published: 08/17/2012