Effect of pre-existing adenovirus neutralizing antibody on vector infectivity and transgene expression

Adenoviruses were identified as unique viruses in 1953 by Rowe and coworkers when virus was isolated from human adenoids. Because adenoviruses infect various cells they are considered an excellent vector delivery system. A major obstacle to efficient infection by recombinant adenoviruses is the humo...

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Author: Noelle Parisi Dahl
Degree Work Type: Thesis (M.S.)
Institution: Villanova University
Format: Degree Work
Language: English
Published: 2010
Subjects:
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