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An animal model of the migration effect

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Description: Adherence to the scalar property (i.e., the observation that the standard deviation of a temporal estimate is proportional to the duration being timed) is a defining characteristic of temporal perception in the seconds to minutes range (Gibbon, 1977). When Parkinson's Disease (PD) patients are tested on a two duration timing task without dopamine (DA) replacement drugs, their duration estimates move towards one another, and the resulting variation in these estimates violates the scalar property; a phenomenon called the migration effect (Malapani et al., 1998). This effect has been shown to result from disturbed memory retrieval (Malapani, Deweer, & Gibbon, 2002). DA deficiency has also been shown to affect timing ability in rodents, but in this case the resulting behavior indicates a slowed clock, which causes an overestimation of time that still conforms to the scalar property (Meck, 1996). To investigate these conflicting findings the current study combined the methods of Malapani et al. and Meck by using rodents as subjects and systemic injections of haloperidol (1.0 mg/kg) to replicate the DA deficiency seen in PD patients. The goal was to produce the migration effect in rodents so that the resulting animal model could be used to further investigate the mechanism of temporal memory retrieval. However, this goal was not achieved due to the haloperidol dose being too high, leading to excessively low response rates.
Language: English
Format: Degree Work