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Interferon-gamma increases CD4+ T cell survival and proliferation

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Description: Recent investigations have revealed that cooperation between innate and adaptive immunity is important in initiating and sustaining an effective immune response against a pathogen. However, the role of the proinflammatory cytokine Interferon-γ (IFN-γ) in bridging the innate and adaptive immune response is not fully understood. IFN-γ is secreted in large quantities by natural killer cells during the innate immune response and by activated cluster differentiation four positive T cells (CD4 + T cells) during the adaptive immune response. The major IFN-γ cell signaling pathway involves signal transducer and activator of transcription 1 (STAT1) and controls the expression of a large number of genes in innate and adaptive immunity. Here, I demonstrate that IFN-γ aids in initiating an effective adaptive immune response by leading to higher levels of CD4 + T cell proliferation in response to antigenic stimulation. This increase in proliferation occurs through a STAT1-independent signaling pathway and does not correlate to increased signaling through the T cell receptor in response to antigenic stimulation. In contrast, I have shown that IFN-γ increases CD4 + T cell survival independent of antigenic stimulation. My findings suggest that IFN-γ may enhance the advent of adaptive immunity by ensuring the survival of CD4 + T cells. (Abstract shortened by UMI.)
Language: English
Format: Degree Work