||The present study explored the extent to which pre-existing semantic knowledge can enhance episodic memory. Subjects studied scenes that were arranged in either a spatially consistent manner or arranged in a spatially neutral manner and then performed a yes/no recognition task. Consistent with previous research, healthy controls' performance was enhanced by spatial coherence. Unexpectedly, however, amnesics showed no benefit of spatial coherence. The lack of effect between the two scene conditions may suggest that spatial coherence does not increase schema activation in amnesics.