||A descriptive qualitative study examined infant care and self-care knowledge acquisition needs and issues among primiparous women of Puerto Rican descent in the post-partum period. With projected Hispanic population growth, health care utilization will increase proportionately. Hispanics have been identified as a population at risk for health disparities and Hispanic women receive fewer preventive services, experience a higher incidence of postpartum complications, and report less satisfaction with the quality of care than non-Hispanic Blacks or Whites. Despite repeated recommendations for research, there has been a dearth of studies on this topic. Data from 22 semi-structured interviews were analyzed using content analysis. Results supported previous findings from the literature regarding the self-care and infant care information needs and concerns of new mothers. However, literacy, language, socioeconomic, and access issues were significant for this cultural group. Social support networks were integral to this group's transition to the maternal role while simultaneously posing new challenges for new mothers. Themes included Self-care teaching received, Infant care teaching received, and Sources of self-care and infant care information. Another theme entitled Transition to motherhood included Physical recovery from childbirth, and Mental adjustment to life-change. Yet another theme emerged was the influence of culture which contained Family influence, Dilemmas of cultural practices, and Cultural conflict. Finally, the participants in this study provided advice to nurses.